domperidone

• Go to Health Canada warning (2015) Domperidone- Association with Serious Abnormal Heart Rhythms and Sudden Death (Cardiac Arrest)

---

---

GERD
Infants and children less than 35 kg

0.4-0.8 mg/kg/dose PO TID . Give 15-30 minutes before feeds/meals/bedtime (as applicable)
Maximum: 10 mg/dose AND 30 mg/24h

OR

0.3-0.6 mg/kg/dose PO QID . Give 15-30 minutes before feeds/meals/bedtime (as applicable)
Maximum: 10 mg/dose AND 30 mg/24h

35 kg and greater

10 mg/dose PO TID . Give 15-30 minutes before feeds/meals/bedtime (as applicable)
Maximum: 30 mg/24h

---

Comments

• Discontinue domperidone if after 4 – 6 weeks there is no clinical response
• Recommend ECG pre initiation and repeat 3-5 days post initiation of domperidone in:
  • All Neonates
  • Patients:
    • with a history of heart rate or rhythm disorders, structural heart abnormalities, hypokalemia
    • with Family history of significant cardiac disease or long QT syndrome
    • on concomitant QT-prolonging drugs or CYP 3A4 inhibitors

---

Go to Neonatal Drug Dosing Guideline for domperidone

---

Supplied

Suspension: 1 mg/mL IWK Compounded
Tablet: 10 mg

---

For more detailed information, go to Micromedex

---

Created on June 12, 2019 02:18 PM
Updated on July 14, 2026 11:15 AM