sodium chloride (hypertonic)

Other Common Name:

• 1 mmol of 3% sodium chloride = 2 mL of 3% sodium chloride
• 3% injection = 0.513 mmol/mL
  
  
• *For doses ordered as mL or mL/kg, parenteral manual calculator is NOT required.  Refer to parenteral manual for administration and monitoring guidelines.

 

 

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Go to NICU Parenteral Administration Information for sodium chloride (hypertonic)

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Asymptomatic Hyponatremia* (serum Na less than 120 mmol/L AND asymptomatic)
Intermittent Infusion/Continuous Infusion

Dose Calculation:
1. calculate dose (mmol) of sodium:
     Dose (mmol of Na) = [desired serum Na* (mmol/L) – actual serum Na (mmol/L)] x 0.7 x weight (kg)
    *For acute correction use 125 mmol/L as the desired serum sodium

2. Use parenteral manual preparation calculator to convert mmol dose to mLs.   
    Pump is programmed in mL/kg/hour

Give dose as intermittent infusion at rate of 1 mL/kg/hour OR 0.5 mmol/kg/hour 
Note: in some situations, dose may be ordered to be administered as a continuous infusion

Maximum: 2 mL/kg/hour OR 1 mmol/kg/hour

Symptomatic Hyponatremia* (Seizures)
Must be ordered under the direction of a neonatologist
Intermittent Infusion: 
1-3 mL/kg/dose (0.5-1.5 mmol/kg/dose) 

NOTE: Too rapid correction of sodium deficit can result in osmotic demyelination syndromes with severe brain injury and potentially death.

Maximum: 6 mL/kg/dose OR 3 mmol/kg/dose

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Comments

• NOTE: 1 mL/kg of 3% NaCl will raise the serum sodium by approximately 1 mmol/L
• Following resolution of symptoms associated with acute hyponatremia, the infusion should be adjusted to increased serum sodium by no more than 8-10 mmol/L per day

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Go to Pediatric Drug Dosing Guideline for sodium chloride (hypertonic)

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Supplied

Inhalation, Nebule: 3 %, 7 %
Injection: 0.513 mmol/mL HIGH ALERT

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For more detailed information, go to Micromedex

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Created on August 25, 2021 02:08 PM
Updated on October 07, 2025 03:27 PM